Pathogenesis Vitiligo Treatment
Posted on December 23rd, 2010
This article talks about Pathogenesis Vitiligo Treatment, Vitiligo Autoimmune Skin Disorder
Vitiligo is autoimmune skin disorder or disease caused by the dis-appearance of pigment cells from the epidermis that results in white patches which are often symmetrically distributed. Lack of melanin skin pigment makes the lesional skin more sensitive to sunburn. Vitiligo can be cosmetically hidden and this stigmatizing condition leads to serious problems in life.
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Vitiligo occurs worldwide in about 0.5% of the population and seen frequently in males and females. The cause of Vitiligo is unknown, but may lead to:
- Autoimmunity
- Genetic Factors
- Lack Of Melanocyte Growth Factors
- Neurologic Factors
- Toxic Metabolites
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In widespread vitiligo pigment can be removed by de-pigmentation agents. Sunscreens camouflage products like dermablend are available.
Pathogenesis Vitiligo Treatment
Many vitiligo treatments are in use for some time but there are some new developments narrowband ultraviolet UV B 311 nm therapy combination of corticosteroid cream, UVA therapy and transplantation of autologous pigment cells in various modalities.
The pathobiology of vitiligo has been hotly disputed for as long as one remembers, and has been a magnet for endless speculation. Evidently, the different schools of thought – ranging,
For Example: From concept that vitiligo essentially is a free-radical skin disorder to that of vitiligo being a primary autoimmune disease – may imply very different consequences for the best therapeutic strategies that one should adopt.
- As a more effective therapy for this common often disfiguring pigmentary disorder is direly needed we must strive harder to settle the pathogenesis debate definitively on the basis of sound experimental evidence rather than by a war of dogmatic theories.
- Recognizing however that it is theories which tend to guide our experimental designs and choice of study parameters the various pathogenesis theories on the market deserve to be critically yet unemotionally re evaluated.
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Vitiligo provides a great model for study of many fundamental problems in skin biology and pathology.
Therefore, even if it later turns out that, as far as your own vitiligo pathogenesis concept is concerned, you have shouted at the wrong tree most of the time, chances are that you shall anyway have generated priceless new insights into skin function along the way.
Pathogenesis Vitiligo Autoimmune Disease Treatment
Various theories have been put forward to explain the pathogenic events leading to melanocyte death and the development of hypopigmented patches. The most commonly accepted hypotheses are autoimmune, autocytotoxic, neural and genetic:
Autoimmune vitiligo hypothesis this is supported by an association with other autoimmune diseases and the detection of serum autoantibodies to melanocytes in patients with active disease especially to melanosomal proteins.
Here are some references on the subject of Pathogenesis Vitiligo Treatment, Vitiligo Autoimmune Skin Disorder
Vitiligo. Pathogenesis and treatment. Am J Clin Dermatol. 2001 PubMed result - PubMed is a service of the U.S. National Library of Medicine that includes over 19 million citations from MEDLINE and other life science journals
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